Synthesis of new Spiropyrazole derivatives under microwaves irradiation and docking study for inhibition the microbes and COVID-19Research article Published on 2022-12-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 6LU7 addition analysis antimicrobial Antiviral binding Candida albican Complete Complexes COVID-19 derivative derivatives docking docking score docking study domain Effectiveness Hydrazonoyl halides indicated inhibit Interaction Laboratory microbe microwave Microwaves physicochemical property protease Seven Spiropyrazoles synthesis tested these compound with COVID-19 [DOI] 10.1016/j.molstruc.2022.133581 [Article Type] Research article
Fungal colonization and infections in patients with COVID-19 in intensive care units: A real-life experience at a tertiary-care hospitalResearch article Published on 2022-11-012022-10-05 Journal: Respiratory medicine and research [Category] 진단, [키워드] age antifungal therapy Antifungal treatment Candida albican Candida albicans Computed tomography COVID-19 COVID-19 diagnosis COVID-19-associated pulmonary aspergillosis cross-contamination diagnostic evaluate exhibited Fatality rate fungal Fungal colonization Fungal infection highlight hospital ICU ICUs Infection intensive care intensive care unit Invasive mechanical ventilation laboratory data management mechanical ventilation medical records men outcome pandemic Patient patients patients with COVID-19 performed problem Result risk Risk factors the patient Thorax women [DOI] 10.1016/j.resmer.2022.100937 [Article Type] Research article
Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybridsResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 1 2 3 3-Triazoles 4-Thiadiazole analogue antimicrobial activity Bacillus subtilis binding affinity Candida albican candidate chalcone chloride Compound COVID-19 drug-likeness enzyme Escherichia coli exhibited FIVE Hydrazonoyl halides identify in silico in vitro inhibitor molecular docking pathogen Prevent proliferation Pseudomonas aeruginosa screened Staphylococcus aureus submitted synthesis synthesised therapeutic activity TMPRSS2 TMPRSS2 enzyme transmembrane serine protease Treatment Vanillin was tested [DOI] 10.1016/j.molstruc.2022.133659 [Article Type] Research article
Hydrothermal assisted biogenic synthesis of silver nanoparticles: A potential study on virulent candida isolates from COVID-19 patientsArticle Published on 2022-10-062022-11-15 Journal: PLoS ONE [Category] 진단, [키워드] atomic biological activity Candida Candida albican Candida albicans Cell cell membrane coated COVID-19 COVID-19 patient effective Fourier transform High-resolution Ion isolate mechanism Microscopy Modification Morphological PCR question reduction silver nanoparticle TEM Testing thymus Till transmission electron microscopy virulence virulent vulgaris [DOI] 10.1371/journal.pone.0269864 PMC 바로가기
Repurposing vilanterol as a novel potential antifungal for Candida albicans: In-silico & in-vitro approachResearch article Published on 2022-09-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] Acridine orange and Ethidium bromide Alter Amino acids CYSCystine Analysis AO/EBAcridine orange and Ethidium bromide approach binding binding free energy C. albican C. albicans Candida Candida albican carried cause cell membrane chronic Conditions obstructive pulmonary disease Clinical and Laboratory Standards Institute clinical study CLSIClinical and Laboratory Standards Institute complex Computational drug Concentration COPDchronic Conditions obstructive pulmonary disease Cystine demethylase diffusion Dimethyl sulfoxide disrupt DMSODimethyl sulfoxide docking method dose drug drug interaction Drug screening drugs Erg11pLanosterol 14-alpha demethylase FDAThe United States Food and Drug Administration fluorescent fungicidal fungicidal activity glycine GLYGlycine Health High-throughput virtual screening HISHistidine histidine HTVSHigh-throughput virtual screening humans In-vitro infect infections inhibitory concentration initial Interaction lanosterol Lanosterol 14-alpha demethylase MDSMolecular Dynamics Simulations MICMinimum inhibitory concentration Microscopy Minimum inhibitory concentration MMGBSAMolecular mechanics energies with generalized born surface area Molecular dynamics simulation molecular dynamics simulations Molecular mechanics energies with generalized born surface area mortality rate PBSPhosphate buffer saline PDBProtein Data Bank Phenylalanine PHEPhenylalanine Phosphate buffer saline Phosphatidylcholines Picoseconds POPCPhosphatidylcholines Protein Data Bank psPicoseconds repurposing Safe SDStandard deviation Serine SERSerine SPStandard-precision Standard deviation Standard-precision tested The United States Food and Drug Administration tyrosine TYRTyrosine Variable-dielectric surface generalized born model 2.0 VSGB 2.0Variable-dielectric surface generalized born model 2.0 XPXtra-precision Xtra-precision Yeast extract/peptone/dextrose YPDYeast extract/peptone/dextrose [DOI] 10.1016/j.medidd.2022.100137 [Article Type] Research article
Organ-specific host differential gene expression analysis in systemic candidiasis: A systems biology approach전신 칸디다증에서 기관 특이적 숙주 차등 유전자 발현 분석: 시스템 생물학 접근법Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] 유전자 메커니즘, [키워드] acquisition Activation acute phase response Analysis approach C. albicans can be used Candida Candida albican Candida albicans Candidemia candidiasis Clinical management Co-infection Complication coronavirus disease COVID-19 COVID-19 infections COVID-19 mortality Critical Defense defense mechanisms develop Differential gene expression differentially expressed gene Differentially expressed genes down-regulated drug effector cells event fungal infections hospital Host hub genes human gene human genes Immune cell immune cells immune response immune responses Infection Interaction invasive involved iron kidney leukocyte liver lymphocyte mechanisms molecular mycotic infection mycotic infections occur organ organ-specific organs pathway proliferation protocol recruitment research finding risk Scientific community severe COVID-19 infections sluggish spleen Surveillance systemic Candidiasis Systems biology therapeutic Therapy. yeast [DOI] 10.1016/j.micpath.2022.105677 PMC 바로가기 [Article Type] Article
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans Research Published on 2022-07-042022-10-05 Journal: Nature Structural & Molecular Biology [Category] 변종, [키워드] binding Candida albican chitin conserved Control cryo-EM structure enzyme activity Extracellular fungal cell wall inhibitor mechanism membrane motif non-specific Prevent Regulation Synthase target translocation unique [DOI] 10.1038/s41594-022-00791-x [Article Type] Research
Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans벤즈브로마론을 항엽산으로 용도 변경하여 칸디다 알비칸스에 대한 새로운 항진균 요법 개발Article Published on 2022-06-182022-09-11 Journal: Journal of molecular modeling [Category] 신약개발, [키워드] Absorption Antifungal antifungal therapy approach Benzbromarone Biosynthesis Candida Candida albican Candida albicans candidiasis coenzyme complex complications Computational drug COVID-19 COVID-19 patient COVID-19 patients develop DHFR dihydrofolate drug resistance Effect enzyme folate Folic acid followed by fungal Fungal infection fungal infections Human identify Immunocompromised Infection inhibitor involved macromolecular Mild molecular molecular docking Mortality nucleotides Probability problem problems repurposing required responsible resulting Severe infection severe infections symptomatic systemic effect systemic effects tetrahydrofolate therapy toxic effects Treatment Virtual screening White-fungus. [DOI] 10.1007/s00894-022-05185-w PMC 바로가기 [Article Type] Article
ACE2 expression in saliva of patients with COVID-19 and its association with Candida albicans and Aggregatibacter actinomycetemcomitansArticle Published on 2022-05-232022-11-16 Journal: F1000Research [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression ACE2 mRNA Actin Aggregatibacter actinomycetemcomitans ALS3 analysis angiotensin-converting enzyme 2 association Bacteria C. albican Candida Candida albican Candida albicans collected contribute control group controls correlation COVID-19 COVID-19 severity determine diabete evaluated expression Fusobacterium Fusobacterium nucleatum Genes groups healthy hospitalized patient hyphal Indonesia investigated involved mRNA expression no significant difference oral microbiota participant Patient patients patients with COVID-19 patients with diabete PCR-confirmed COVID-19 performed Prognosis proportion Protein protein 3 qPCR quantitative PCR Saliva SARS-COV-2 infection selected significantly higher subject susceptibility Swab swab sample the patient tongue Transcription Veillonella parvula. [DOI] 10.12688/f1000research.111965.2 PMC 바로가기
Inactivation of SARS-CoV-2 by a chitosan/α-Ag2WO4 composite generated by femtosecond laser irradiation Research Published on 2022-05-172022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] addition analyzed Anti-SARS-CoV-2 Activity Bacteria Candida albican Candida albicans carried Cell cell culture supernatant Community Concentration Contact controls COVID-19 pandemic cytotoxicity Effect Escherichia coli inhibitory concentration kill MTT outcome Prevent quantification quantified reduced ROS production SARS-CoV-2 Spread Staphylococcus aureus the SARS-CoV-2 Vero E6 cell viral titer virucidal virus was determined yeast [DOI] 10.1038/s41598-022-11902-5 [Article Type] Research